By Michel Bégin, Product Line Manager, Fiber Laser, indie’s Photonics BU In the evolving landscape of digital histopathology and biomedical research, the demand for real-time, non-destructive imaging has never been greater. Traditional staining-based workflows, while effective, are slow, labor-intensive, and introduce variability. Enter label-free nonlinear imaging—a technique that leverages intrinsic tissue contrast without dyes, enabling faster and more accurate diagnostics. Why Label-Free Imaging Matters Label-free imaging techniques such as Second…
Customer Background Dr. Kayvan Forouhesh Tehrani is an experienced biophotonics engineer specializing in microscopy and bioimaging and is the founder and CEO of Eleuthra Photonics. Eleuthra Photonics specializes in developing and producing rapid image-based diagnostic tools for analyzing tissue and cell samples, with a primary focus on cancer and other disease diagnoses. Eleuthra’s Tetraquant™ platform provides multimodal nonlinear imaging technology through the use of a single femtosecond excitation laser. The…
Discover how ultrafast lasers and terahertz (THz) technology are transforming industries with insights from Michel Begin, an expert in advanced photonics solutions. Learn about THz generation, femtosecond fiber lasers, and the exciting future of this groundbreaking technology. Michel, what makes THz radiation special compared to other spectral bands of the electromagnetic spectrum? THz waves have unique properties that set them apart. They can penetrate various non-conductive materials such as plastics, fabrics,…
Multiphoton microscopy is an advanced imaging technique that leverages the simultaneous absorption of multiple photons to excite fluorophores, generating a signal only at the focal point of the laser beam. This unique characteristic enables deeper tissue penetration, reduced out-of-focus light interference, and minimal phototoxicity, making it an indispensable tool for imaging living cells, neuronal structures, and complex biological environments. Additionally, this technique allows for real-time, high-resolution imaging of dynamic processes,…
In two-photon microscopy, green fluorophores excited with 920 nm femtosecond lasers have been the standard choice for researchers. However, there is an increased interest in the use of red fluorophores such as mCherry or tdTomato that requires excitation at longer wavelengths near 1064 nm. At the same time, the ability to combine 920 nm and 1064 nm light sources is becoming more popular, paving the way for advanced multicolour imaging…
Femtosecond lasers offer numerous opportunities, influencing advancements in scientific, medical and industrial fields. Currently, a wide array of ultrafast laser products is available, emitting at various wavelengths in the near-infrared and visible ranges. In recent years, there has been a notable emergence of several alternatives to aging, complex, expensive, and often unreliable ultrafast lasers from established players. In this application note, we discuss how to choose a laser source that…
The indie team has developed a new generation of 488nm Fabry-Perot laser diodes (FP-LDs) with best-in-class conversion efficiency, good control of emission wavelength and long-term reliability.These new devices will support a wide range of applications, and are particularly suited for fluorescence microscopy, flow cytometry and spectroscopy. As of now, the LDs are available as uncooled TO56 cans (Product No. ELA350003-01) with free-space light output and include a monitor photodiode for…
Fiber lasers producing ultrashort pulses (also known as ultrafast fiber lasers) offer many advantages over their solid-state counterpart, driving their increasing adoption in a wide range of industrial, biomedical and scientific applications. Most ultrafast laser systems are based on passive mode-locked oscillators, often relying on a saturable absorber that has low loss for high intensities and high loss for low intensities. Different physical phenomena usually occur in the cavity, including…
Introduction Short-pulse lasers are used in countless applications, including in material processing, refractive surgery, multi-photon imaging, semiconductor inspection, and a host of scientific uses. For laser manufacturers, this great diversity encourages the development of flexible technology platforms that must be configured according to the needs of end users. Managing this flexibility and these various configurations is often a challenge; in fact, several factors can complicate achieving the target performance in…
In recent years, the market for 2 μm high-power fiber lasers has witnessed remarkable expansion, driven by the emergence of diverse applications. Consequently, there is now a pressing demand for highly reliable and high-performance FBG reflectors as will be discussed in this application note. Introduction Fiber lasers operating within the 2 μm wavelength range are rapidly finding utility in a diverse array of applications, including medical surgery, solid-state laser pumping,…
Introduction Fibre lasers provide many advantages that are driving their adoption in a growing number of applications that until recently relied on other laser technologies (solid-state crystal lasers, gas lasers, semiconductors, etc.). Therapeutic applications of lasers have existed since their introduction in the 1960s, and have continued to multiply and be refined ever since. The therapeutic fibre laser represents a significant refinement as it opens up new possibilities to improve…
Chirped-Pulse Amplification (CPA), based on ultrafast lasers (Figure 1), are in-demand versatile processing tools. They often operate in extreme physical conditions: several hundred Watts to Kilowatts of average power in MHz-GHz repetition rate regime, combined with pulse duration often below a picosecond, give rise to intense pulse in MW to GW peak power. Ultra-Short Pulse (USP) lasers are becoming a vital backbone in diverse applications. Whether it is for micro-machining…
